Psilocybin Laws in Colorado

Colorado's Natural Medicine Health Act (Proposition 122, effective December 27, 2022) allows adults 21 and older to possess, consume, share without payment, cultivate and make psilocybin and psilocin (and DMT, mescaline other than peyote, and ibogaine) for personal use, and creates state-licensed healing centers where licensed facilitators supervise natural medicine services. Selling natural medicine outside the licensed program, giving it to anyone under 21 or using it commercially remains illegal. A person under 21 who possesses or consumes it commits a drug petty offense (fine up to $100 or up to four hours of substance use education or counseling), and public display or consumption is a drug petty offense (fine up to $100 and up to 24 hours of public service). Psilocybin and psilocyn are still listed in Schedule I. Later laws let the governor pardon a class of people convicted of possessing natural medicine (SB 25-297, signed June 3, 2025), legalize an FDA-approved crystalline polymorph psilocybin medicine once approved (HB 25-1063, signed March 31, 2025), and create an ibogaine research pilot program (HB 26-1325, signed June 4, 2026).